Dr. Alexander Skupin (AS − coordinator) leads the Integrative Cell Signalling group. Its approach is to combine state-of-the-art imaging and single-cell techniques with mechanistic modelling and bioinformatics analyses to investigate how the emergent behaviour of cells, organs and organisms originates from molecular entities. To understand the underlying cell signalling mechanisms, the group focuses on live cell imaging and multi-scale simulations with consideration of (epi)genetic constraints. The major interests of the group are signalling pathways related to Parkinson’s Disease with a particular focus on mitochondrial dysfunction and dynamic coupling between energy metabolism and cell signalling such as Ca2+ dynamics. Therefore, the group uses diverse cell lines and phenotyping assays including sophisticated image analysis, single-cell platforms and methods based on information theory to reveal the dynamic consequences of disease-related perturbations at single-cell resolution.
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