Dr. Anne Grünewald (AG) leads the Molecular and Functional Neurobiology group at LCSB. One of the research objectives of the Molecular and Functional Neurobiology group at LCSB is to explore how changes in the integrity of the mitochondrial genome contribute to respiratory chain deficiency in Parkinson’s Disease. As the mitochondrial genome exists in multiple copies per cell, somatic mtDNA mutations, copy number variations and consequent respiratory phenotypes may arise at varying levels. To investigate this link between the mitochondrial genome (mtDNA), mitochondrial dysfunction and neurodegeneration, single-cell analysis techniques are required. The group specialises in single-cell proteomic and DNA analysis approaches, which will be applied to post-mortem brain tissue and cell cultures within the framework of the DTU.
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